Diagnosis, initial management, and prevention of meningitis david m. Nucleotide sequence of the herpes simplex virus type 2 thymidine kinase gene. Mollarets meningitis and herpes simplex virus type 1 nejm. Recurrent benign lymphocytic meningitis clinical infectious. Recurrent aseptic meningitis secondary to intracranial epidermoids. This may not be the complete list of references from this article. Ct cisternogram coronal reformat showing leakage of intrathecally. Since mollarets meningitis is a recurrent, benign noncancerous, aseptic meningitis, it is also referred to as benign recurrent lymphocytic meningitis. Mollaret meningitis was first described by mollaret in 1944 as a form of aseptic meningitis. However, recent research and studies have suggested that it may be more common than initially thought. Mollarets meningitis and differential diagnosis of recurrent meningitis. Benign recurrent aseptic meningitis, also called mollaret s meningitis, is a rare, albeit well described disease. Picard fj, dekaban ga, silva j, rice gp 1993 mollaret s meningitis associated with herpes simplex type 2 infection. Mollaret was the first to describe a rare form of meningitis that presented as recurrent and brief selflimiting attacks of fever, headache, vomiting, and meningeal irritation with no obvious etiology.
What links here related changes upload file special pages permanent. Mollarets meningitis fulltext european neurology 2008, vol. Recurrent benign lymphocytic meningitis is a recurring, typically innocuous, painful form of. Get a printable copy pdf file of the complete article 869k, or click on a page. We present a case of a 27yearold woman with mollarets meningitis related. A 72yearold woman, previously in good health, suffered for 2 years from attacks of a complex neuropsychiatric syndrome lasting from 2 days to 4 weeks. Clinical diagnosisthe classical symptoms and signs of acute meningitis. Bamberger, md, university of missourikansas city school of medicine, kansas city, missouri a cute meningitis is a medical emer. Clinical symptoms include headache, stiff neck, high fever, nauseavomiting and rash.
However, injuries, cancer, certain drugs, and other types of infections also can cause meningitis. A form of meningitis which manifests with sudden attack of fever and meningeal signs with an increased csf pressure. A rare form of aseptic meningitis characterized by a recurrent pattern with symptomfree intervals between episodes. The syndrome of benign recurrent aseptic meningitis of unknown cause is called mollarets meningitis. Mollaret s meningitis wikiproject medicine rated lowimportance this article is within the scope of wikiproject medicine, which recommends that this article follows the. The exact etiology is unknown though herpes simplex virus is now thought to be the most likely pathogen. Mollarets meningitis and differential diagnosis of recurrent. Mollarets meningitisrecurrent aseptic meningitishsv2 virus. Mollaret meningitis article about mollaret meningitis by. Pdf mollaret meningitis mm occurs mainly in females and is characterized by. Mollaret s meningitis and differential diagnosis of recurrent meningitis. It is characterized by repeated episodes of meningitis. Here we present an atypical case of mollaret s meningitis in which the patient presented with headache and meningismus in the absence of fever. However, there has been associated with viruses, especially herpes simplex virus type 1.
Mollarets meningitis is a recurrent or chronic inflammation of the protective membranes. A rare disease characterized by recurrent episodes of aseptic meningitis was discovered by mollaret and named after him called mollaret s meningitis. Difficult and recurrent meningitis journal of neurology. Meningitis arising by this route is called primary bacterial meningitis. Mollaret meningitis is recurrent bouts of benign aseptic not due to a bacteria meningitis in which the etiology has not been identified. Mollaret meningitis, recurrent aseptic meningitis, fever. When can the management of meningitis become difficult. Mollaret s meningitis is a rare condition with a characteristic clinical and cerebrospinal fluid picture. The 35yearold praised simon read and matthew laws from the east of england ambulance service nhs trust eeast for their care after her condition rapidly deteriorated. Mollaret s meningitis, first described by mollaret. Hence, the name mollaret meningitis is frequently associated with the syndrome. Find mollaret s meningitis information, treatments for mollaret s meningitis and mollaret s meningitis. Hsv2 diagnostico mediante pcr sesiones generales caule.
Cerebrospinal fluid csf examination remains the sole diagnostic. Mollarets meningitis an overview sciencedirect topics. Broadly speaking, there are three main potential areas of concern. Pdf herpes simplex virus type 2 mollarets meningitis. Meningitis meningitis is a severe illness characterized by serous inflammation of the linings of the brain and spinal cord meninges. Whereas, mollaret s meningitis awareness day provides an opportunity for families whose lives have been affected to honor dedicated health professionals, and to meet others and know they are not alone.
Clinical diagnosisthe classical symptoms and signs of acute meningitis may be absent in the very young, the very old and the very sick. We report a case of mollaret meningitis in a sevenyearold girl who presented with four aseptic meningitis episodes in one year. Benign recurrent aseptic meningitis mollarets meningitis. If you have problems viewing pdf files, download the latest version of. Mollaret meningitis genetic and rare diseases information center. Pierre mollaret 10 july 1898 3 december 1987 was a french neurologist who made significant scientific contributions to the study of infectious diseases and neurology. Recurrent lymphocytic meningitis rlm is a rare disease, characterized by attacks of sudden onset aseptic meningitis followed by complete recovery and unpredictable recurrences. Analysis of candidatehost immunogenetic determinants in herpes. Mollarets meningitis benign recurrent aseptic meningitis. Mollarets meningitis is a rare form of idiopathic recurrent aseptic meningitis that has a sudden onset, short duration, and spontaneous remission with unpredictable recurrence. Get a printable copy pdf file of the complete article 869k. We report a case of a 41year old woman who experienced three episodes of aseptic meningitis.
Meningitis is an inflammation swelling of the protective membranes covering the brain and spinal cord. Mollarets meningitis is a rare form of benign, recurrent aseptic meningitis characterized by the appearance of a particular mononuclear cell in the csf during the first few days of the illness. Mollarets meningitis is a condition that causes recurring viral meningitis. Mollarets meningitis recurrent aseptic meningitishsv2 virus. Mollaret s meningitis mm is a rare disease of benign nature characterized by recurrent episodes of aseptic meningitis. A bacterial or viral infection of the fluid surrounding the brain and spinal cord usually causes the swelling. Pdf mollarets meningitis is an unusual and underappreciated syndrome of benign, recurrent aseptic meningitis. They were identical to those in an entity known as mollarets meningitis and ours is the first recorded instance of this disease in the.
Recurrent lymphocytic meningitis positive for herpes. Herpes simplex virus type 2associated recurrent aseptic. Aseptic meningitis often has a similar presentation to that of bacterial meningitis ie, fever, headache, altered mental status, stiff neck, photophobia, which can be a lifethreatening illness. Patients with a clinical diagnosis of mollarets meningitis were identified as having repeated attacks. Secondary meningitis is that which develops following direct entry of bacteria into the central nervous system, which can occur at the time. Pdf mollarets meningitis is an unusual and underappreciated syndrome of. Mollarets meningitis is a recurrent or chronic inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. Diagnosis of mollaret meningitis mollaret meningitis is characterized by recurrent episodes of severe headache, meningismus, and fever. Pdf mollarets meningitis is a rare disease characterized by recurrent and selflimited episodes of lymphocytic meningitis. Mollaret s meningitis also referred to as recurrent benign lymphocytic meningitis, is characterized by a transient and recurrent onset of neurological symptoms such as headaches, fever, meningismus and.
Pdf mollaret meningitis may be caused by reactivation of latent. Diagnosis, initial management, and prevention of meningitis. The disease is characterised by recurrent at least three episodes, benign no longterm sequelae and brief 25 day episodes of aseptic lymphocytic meningitis. Cooper declares may 1, 2017 mollaret s meningitis awareness day. Mollaret s meningitis is caused by herpes simplex virus. Mollarets meningitis should be suspected in all cases of recurrent lymphocytic meningitis. Mollarets meningitis is a rare disease characterized by recurrent and selflimited episodes of lymphocytic meningitis. Mollaret meningitis is a type of meningitis due to a viral infection aseptic meningitis that occurs multiple times. In many ways it resembles recurrent hereditary polyserositis familial mediterranean.
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